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Sildenafil increases cerebrovascular reactivity: a transcranial Doppler study.

Diomedi M, Sallustio F, Rizzato B, Ferrante F, Leone G, Spera E, Scarfini M, Bernardi G

Fondazione Santa Lucia IRCCS, Rome, Italy. marina.diomedi@uniroma2.it

The authors performed a double-blind, placebo-controlled study in 28 patients to evaluate the effects of sildenafil on cerebral hemodynamics. A significant improvement of cerebrovascular reactivity, without any modification of other variables, was recorded 1 hour after the administration of 50 mg sildenafil. Further investigations are needed to evaluate whether cerebrovascular reactivity improvement could contribute to triggering sildenafil-induced migraine.

Published 27 September 2005 in Neurology, 65(6): 919-21.
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