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Should phosphodiesterase 5 selective inhibitors be used for uterine relaxation?

Méhats C, Schmitz T, Breuiller-Fouché M, Leroy MJ, Cabrol D

Institut National de la Santé et de la Recherche Médicale, INSERM U427 Paris, Faculté de Pharmacie, France. mehats@cochin.inserm.fr

Sildenafil citrate is a phosphodiesterase 5-selective inhibitor used successfully in treating erectile dysfunction. High doses of sildenafil can inhibit myometrial contractions. However, no study has demonstrated a role for phosphodiesterase 5 in myometrial contractility. No clinical trial using sildenafil to promote uterine relaxation should be initiated based on the currently available data.

Published 3 July 2006 in Am J Obstet Gynecol, 195(1): 184-5.
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