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Changes in clitoral blood flow in premenopausal women affected by type 1 diabetes after single 100-mg administration of sildenafil.

Caruso S, Rugolo S, Mirabella D, Intelisano G, Di Mari L, Cianci A

Department of Microbiological and Gynaecological Science, University of Catania, Catania, Italy. scaruso@unict.it

OBJECTIVES: To verify whether sildenafil is effective in modifying clitoral blood flow in premenopausal women affected by type 1 diabetes. METHODS: The setting was a diabetes outpatient clinic in which 30 premenopausal women affected by type 1 diabetes treated with insulin therapy and 39 healthy premenopausal women participated in our prospective open-label clinical study. Each diabetic woman received a single oral dose of 100 mg sildenafil. Translabial color Doppler ultrasonography was used to measure the resistance index, pulsatility index, peak systolic velocity, and end-diastolic velocity of the clitoral arteries 1 and 4 hours after sildenafil intake. RESULTS: One hour after the administration of sildenafil, the mean resistance index was significantly lower and the mean pulsatility index, mean peak systolic velocity, and mean end-diastolic velocity of the clitoral arteries were significantly greater compared with baseline and 4 hours after sildenafil (P <0.05). The baseline clitoral blood flow of the diabetic women was lower compared with that of the control group (P <0.001). CONCLUSIONS: Sildenafil seems to improve the clitoral blood flow of premenopausal women with type 1 diabetes.

Published 17 July 2006 in Urology, 68(1): 161-5.
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