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The role of pharmacokinetics and pharmacodynamics in phosphodiesterase-5 inhibitor therapy.

Mehrotra N, Gupta M, Kovar A, Meibohm B

1Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.

Differences in clinical pharmacology of the currently marketed phosphodiesterase (PDE)5 inhibitors sildenafil, vardenafil and tadalafil are largely determined by their pharmacokinetic (PK) properties and their PDE5 inhibitory activity profile. This review outlines the basic concepts of pharmacokinetics and pharmacokinetic pharmacodynamic (PK/PD) relationships and their relevance to dose selection and applied pharmacotherapy. It is followed by a detailed comparative discussion on the pharmacokinetics and exposure-response relationship of the currently available PDE5 inhibitors, including known drug-drug interactions and dosage adjustments in special populations. The review is aimed at providing a critical assessment of the pharmacokinetics of PDE5 inhibitors, which may assist clinicians in tailoring drug and/or treatment regimens to the unique needs of each individual patient with erectile dysfunction.International Journal of Impotence Research advance online publication, 21 September 2006; doi:10.1038/sj.ijir.3901522.

Published 21 September 2006 in Int J Impot Res.
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