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The Effects of Sildenafil on Heart Rate Variability in Healthy Subjects.

Siepmann M, Rauh R, Dill O, Agelink MW, Mueck-Weymann M

From the *Institute of Clinical Pharmacology, Medical Faculty, Technical University, Dresden, Germany; †Institute of Cellular and Molecular Physiology, Friedrich-Alexander-University, Erlangen, Germany; ‡Clinic for Psychiatry, Psychotherapy and Psychosomatic Medicine, Herford and Ruhr University, Bochum, Germany; and §Institute of Behavioural Medicine and Prevention, University for Health Sciences, Medical Informatics and Technology, Hall, Austria.

The effects of sildenafil on heart rate variability were investigated in 20 healthy male subjects aged 24 (21 to 32) years (median; range). Subjects orally received single 100-mg doses of sildenafil and placebo under randomized double-blind crossover conditions on 2 separate study days. Time domain measures of heart rate variability were assessed under conditions of relaxed rest, metronomic breathing (6 cycles per minute), and bicycle ergometry before administration of sildenafil and placebo as well as 60 minutes afterwards. Sildenafil did not alter heart rate nor heart rate variability to a significant extent (P > 0.05).

Published 21 November 2007 in J Cardiovasc Pharmacol, 50(5): 598-600.
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