Viagra Research Today is a free monthly online journal that collates and summarizes the latest research about Viagra, including details on sildenafil, erectile dysfunction, impotence, side-effects, alternatives.

Chronic sildenafil in men with diabetes and erectile dysfunction.

Aversa A, Bruzziches R, Vitale C, Marazzi G, Francomano D, Barbaro G, Spera G, Rosano GM

1University of Rome ‘La Sapienza’, Dept of Medical Pathophysiology, Viale Policlinico 155 – 00161 Rome, Italy, 2IRCCS San Raffaele, Centre for Clinical and Basic Research, Department of Medical Sciences, Via Della Pisana 235, 00166, Rome, Italy.

Erectile dysfunction frequently represents a neurovascular complication of diabetes mellitus, and it has been calculated that almost 50% of diabetic men will have erectile dysfunction within 6 years after diagnosis. Penile endothelial and smooth muscle cell dysfunction are due to molecular pathway abnormalities (i.e., activation of PKC, increased oxidative stress and overproduction of advanced-glycosylation end products). The response rate to oral drug therapies, such as sildenafil, is lower than in most other groups. Because therapeutic alternatives (i.e., intracavernous injections with vasoactive agents) are not curative, clinical trials aimed to demonstrate rehabilitative effects with daily phosphodiesterase type-5 inhibitors are ongoing. If this approach proves successful, it will determine many advantages over the intracavernosal treatment and potentially induce sexual rehabilitation.

Published 1 June 2007 in Expert Opin Drug Metab Toxicol, 3(3): 451-464.
Full-text of this article is available online (may require subscription).

© 2004-2008 Viagra Research Today. All Rights Reserved.