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An easy synthesis of 5-functionally substituted ethyl 4-amino-1-aryl- pyrazolo-3-carboxylates: interesting precursors to sildenafil analogues.

Ghozlan SA, Badahdah KO, Abdelhamid IA

Department of Chemistry, Faculty of Science, Cairo University, Giza, A, R, Egypt. s_ghozlan@yahoo.com.

ABSTRACT: 3-Oxo-2-arylhydrazononitriles 1a-c react readily with chloroacetonitrile, ethyl chloroacetate, and with phenacyl chloride to give 4-aminopyrazoles 4a-e. The pyrazolo[4,3-d]pyrimidine derivatives 7 and 10 are synthesized via reaction of the aminopyrazole 4b with phenylisothiocyanate and DMFDMA/NH4OAc respectively.

Published 1 June 2007 in Beilstein J Org Chem, 3: 15.
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