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Identification of a novel vardenafil analogue in herbal product.

Lam YH, Poon WT, Lai CK, Chan AY, Mak TW

Hospital Authority Toxicology Reference Laboratory, Princess Margaret Hospital, Lai King Hill Road, Lai Chi Kok, Hong Kong Special Administrative Region, Hong Kong, China.

A new herbal health product marketed for enhancing erectile function, namely Power58 Platinum, was purchased over-the-counter in Hong Kong. The product was tested for adulteration with sildenafil, tadalafil, and vardenafil as well as their structurally modified analogues. A new analogue of vardenafil, in which the N-ethylpiperazine ring and the sulphonyl group were removed from the vardenafil structure, was identified in the product.

Published 12 February 2008 in J Pharm Biomed Anal, 46(4): 804-7.
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