Viagra Research Today is a free monthly online journal that collates and summarizes the latest research about Viagra, including details on sildenafil, erectile dysfunction, impotence, side-effects, alternatives.

PDE5 inhibitors for cystic fibrosis: can they also enhance chloride transport? Evaluation of: Lubamba B, Lecourt H, Lebacq J, et al. Preclinical evidence that sildenafil and vardenafil activate chloride transport in cystic fibrosis. Am J Respir Crit Care Med 2008;177(5):506-15.

Antoniu SA

University of Medicine and Pharmacy Iasi, Pulmonary Disease University Hospital, Division of Pulmonary Disease, 30 Dr I Cihac Street, 700115 Iasi, Romania. sabina.antonela.antoniu@pneum. umfiasi.ro

BACKGROUND: Many compounds are currently under investigation for cystic fibrosis (CF), a genetic disorder caused by various mutations in cystic fibrosis transmembrane regulator (CFTR). OBJECTIVE: To evaluate a preclinical study on the effects of sildenafil and vardenafil, two PDE5 inhibitors, on ion transport in CF animal models. METHODS/RESULTS: The effects of sildenafil and vardenafil on chloride and sodium conductance were assessed in both DeltaF508CFTR and CFTR knockout mice models. They improved chloride transport in the DeltaF508CFTR model and had no effects in the CFTR knockout model. CONCLUSION: Sildenafil and vardenafil are promising agents for CF therapy provided they also demonstrate clinical efficacy.

Published 21 May 2008 in Expert Opin Investig Drugs, 17(6): 965-8.
Full-text of this article is available online (may require subscription).

© 2004-2008 Viagra Research Today. All Rights Reserved.